No. 17 Duke will play one of its biggest college football games of the past decade when it hosts No. 11 Notre Dame in primetime on Saturday night during the Week 5 college football schedule. The Blue Devils improved to 4-0 with a blowout win at UConn last week, and they have also picked up wins over Clemson and Northwestern. They are 5.5-point home underdogs against Notre Dame in the Week 5 college football odds from SportsLine consensus. The Fighting Irish are coming off a 17-14 heartbreaking loss to Ohio State, as the Buckeyes scored the go-ahead touchdown with one second remaining.
Some of the other intriguing Week 5 college football spreads include No. 8 USC (-22) at Colorado, No. 3 Texas (-17) vs. No. 24 Kansas and No. 13 LSU (-2.5) at No. 20 Ole Miss. Which teams should you include in your Week 5 college football bets? Before locking in any Week 5 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.
Now, it has turned its attention to the latest college football odds for Week 5 and locked in picks for every FBS matchup. Head here to see every pick.
Top college football predictions for Week 5
One of the college football picks the model is recommending for Saturday: Georgia (-14.5) covers the spread at Auburn in a 3:30 p.m. ET SEC on CBS kickoff at Jordan-Hare Stadium. The Bulldogs have been disappointing their bettors all month, failing to cover the spread in each of their first four games. However, they are facing an Auburn team that has gone winless against the spread in its last three games, including a 27-10 loss at Texas A&M last week.
Georgia cruised to a 42-10 win over Auburn last year, covering the spread as a 27.5-point favorite. The Bulldogs have won and covered in six consecutive meetings between these teams, while Auburn has only covered once in its last 10 games in the month of September. SportsLine’s model expects both of those trends to continue on Saturday, as Georgia is covering the spread in well over 60% of simulations.
Another prediction: Michigan State (+11.5) plays a competitive road game at Iowa on Saturday at 7:30 p.m. ET. Iowa has been seeking an improved offense for several years, and there were some positive signs for the Hawkeyes early this season. They faced their first elite defense last week though, getting held to just 76 total yards in an embarrassing shutout loss to Penn State.
Michigan State’s defense held Central Michigan and Richmond to a combined 21 points in its first two games this season, while Washington’s red-hot offense scored a season-low 41 points in their Week 3 meeting. Offensively, sophomore running back Nate Carter leads Michigan State with 369 rushing yards and four touchdowns, averaging 5.1 yards per carry. Carter is averaging more than five yards per carry in the model’s latest projections for this game, which is one reason why Michigan State is covering the spread in more than 70% of simulations. See which other teams the model likes here.
How to make college football picks for Week 5
The model has also made the call on who wins and covers in every other FBS matchup in Week 5, and it’s calling for several underdogs to win outright. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned nearly $2,500 in profit since its inception, and find out.
College football odds for top Week 5 games
See full Week 5 college football picks, odds, predictions here
Thursday, Sep. 28
Temple vs. Tulsa (-4, 54.5)
MTSU vs. Western Kentucky (-7, 60.5)
Jacksonville State vs. Sam Houston State (+6.5, 36.5)
Friday, Sep. 29
Louisville vs. NC State (+3, 55)
Louisiana Tech vs. UTEP (-1, 53)
Utah vs. Oregon State (-3, 45.5)
Cincinnati vs. BYU (-2.5, 50)
Saturday, Sep. 30
Florida vs. Kentucky (-2.5, 46)
Clemson vs. Syracuse (+7, 52.5)
Penn State vs. Northwestern (+26, 46)
USC vs. Colorado (+22.5, 73.5)
Georgia vs. Auburn (+14.5, 47.5)
Michigan vs. Nebraska (+18, 41)
Kansas vs. Texas (-17, 62)
Missouri vs. Vanderbilt (+13.5, 56.5)
LSU vs. Ole Miss (+3, 63)
Oregon vs. Stanford (+27, 61)
Iowa State vs. Oklahoma (-20, 48.5)
Notre Dame vs. Duke (+5.5, 51)
South Carolina vs. Tennessee (-12.5, 62)
Alabama vs. Mississippi State (+14.5, 48.5)
Washington vs. Arizona (+17.5, 69.5)
Nevada vs. Fresno State (-24.5, 53.5)